IN THE SPOTLIGHT SPSB1 May Have MET Its Match during Breast Cancer Recurrence
نویسندگان
چکیده
Authors’ Affi liations: 1 Hematology Division, Department of Medicine, Brigham & Women’s Hospital, Harvard Medical School; 2 Harvard Stem Cell Institute, Boston; and 3 Broad Institute of Harvard and MIT, Cambridge, Massachusetts Corresponding Author: Sandra S. McAllister, Brigham & Women’s Hospital, 1 Blackfan Circle, Karp 5-214, Boston, MA 02115. Phone: 617-355-9059; Fax: 617-355-9093; E-mail: [email protected] doi: 10.1158/2159-8290.CD-14-0505 ©2014 American Association for Cancer Research. Summary: Disease recurrence is the most common cause of death for patients with breast cancer, yet little is known about the molecular mechanisms underlying this process. Using inducible transgenic mouse model systems, Feng and colleagues identifi ed SPSB1 as a determinant of breast cancer recurrence by virtue of its ability to protect tumor cells from apoptosis through c-MET activation. Cancer Discov; 4(7); 760–1. ©2014 AACR.
منابع مشابه
SPSB1 may have MET its match during breast cancer recurrence.
SUMMARY Disease recurrence is the most common cause of death for patients with breast cancer, yet little is known about the molecular mechanisms underlying this process. Using inducible transgenic mouse model systems, Feng and colleagues identified SPSB1 as a determinant of breast cancer recurrence by virtue of its ability to protect tumor cells from apoptosis through c-MET activation.
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